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The deer drug 1- 4-methylphenyl methylaminopropanone 4-methylmethcathinone, mephedrone is reported to possess psychostimulant, entactogenic and hallucinogenic effects. The purpose of this study was to examine the effects of acute administration of mephedrone on extracellular levels of dopamine DA and 5-HT in the nucleus accumbens of awake rats and compare these effects with those induced by 3,4-methylenedioxymethamphetamine MDMA, ecstasy and amphetamine. Microdialysis sampling was performed USA Wellington latino simultaneously recording locomotor activity in rats and the monoamines were determined by HPLC with electrochemical detection. Locomotor activity was increased most by amphetamine, whereas both mephedrone and MDMA showed about three times lower and shorter-lasting effects.
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